Disease burden can be measured in many ways. This is particularly important for AORC, which has a modest effect on conveniently measured outcomes like mortality, but a much larger impact on less conveniently measured outcomes important to functionality for most people. Such outcomes include effects on work, health-related quality of life, independence, and ability to keep doing valued life activities. Three of these burdens, along with adverse life style factors that are associated with arthritis, are addressed in the estimates below.