Osteogenic sarcoma exhibits a bimodal distribution, with the significant second peak in incidence occuring in the seventh and eighth decades of life. Osteosarcoma in the elderly can also be attributed to Paget’s disease or previous radiotherapy. The expectation that these elderly patients may not tolerate aggressive modern chemotherapy means that those who develop OS over the age of 40 years are excluded from current treatment trials. As a result, remarkably little is known about the outcome for this age group.1
The overall incidence of tumors of the musculoskeletal system is lower than many types of cancers. This is particularly true for primary cancers of the bones and joints, although bones and joints are frequently a site of secondary, or metastasized, cancers. The occurrence of cancers of the bones and joints affects all ages and is one of the primary cancers in young people. Myeloma, cancer of the bone marrow, is a disease of the elderly, with nearly two-thirds of cases found in people ages 65 years and older. Soft tissue cancers affect all ages, but the occurrence increases with age. (Reference Table 9B.7 PDF [1] CSV [2])
Links:
[1] https://www.boneandjointburden.org/docs/T9B.7.pdf
[2] https://www.boneandjointburden.org/docs/T9B.7.csv